An escaped lion puts lives and relationships in danger; Lexie hears Mark talking about moving in with Julia; Teddy begins to come to terms with Henry's death; Callie asks Arizona about her past relationships.
Cristina makes Owen tell her about the intimate details of his affair; Mark takes his authority very seriously when he steps in as chief for the day; Arizona, Callie and Bailey plan special night for Teddy.
The doctors treat a Jane Doe who turns out to be the subject of a nationally followed case; the residents begin their interviews for post-residency positions; Richard faces a disturbing realization while visiting Adele.
The residents travel to San Francisco for the oral boards; sparks fly when Richard and Catherine (Debbie Allen) bump into each other at a hotel; Alex feels guilty about being away from the hospital when Tommy's health takes a turn for the worse.
The residents agonize over their upcoming exam results; Arizona's childhood friend needs medical help; the doctors try to help a patient who is missing one third of his skull; Julia wants to start a family with Mark.
The residents choose their future positions; Mark admits to Derek that he still has feelings for Lexie; Arizona encourages her friend to have surgery.
A dangerous situation leaves the doctors fighting to stay alive while trying to save their peers; Ben and Bailey make a decision; Teddy gets a tempting offer; Richard plans a dinner for the residents.
Following a plane crash, the doctors of Seattle Grace try to cope with loss, adapt to changes and move forward with their lives.
The doctors try to cope with heartache and injuries caused by the plane crash; everyone at Seattle Grace struggles to return to normalcy amid the chaos.