An elevated train crash interrupts the grand opening of the emergency department when an influx of crash victims arrive at Chicago Med.
Ethan finds himself at odds with Natalie and Sharon when it comes to the treatment of a troubled teenager who's just given birth; Dr. Halstead treats a hypochondriac with an overbearing wife.
Dr. Connor Rhodes is reunited with his sister as he treats a family friend; Dr. Natalie Manning must persuade a young musician to undergo a life-saving surgery that could destroy her hearing.
The doctors treat those injured in a movie theater shooting; Natalie asks Daniel for help treating a teenager with an eating disorder; a patient surprises everyone.
Rhodes and Zanetti race to save a member of Firehouse 51; April's brother struggles during his first day at the hospital; a woman saved from a burning building leads to a bigger mystery.
Airplane stowaways are brought to the hospital with significant injuries; Cornelius Rhodes (D.W. Moffett) is honored after making a large donation to the hospital; Dr. Manning's mother-in-law (Annie Potts) misunderstands Dr. Halstead's intentions.
A patient's life is in jeopardy when legal issues complicate an essential bone marrow transplant; Dr. Charles comes to an unusual conclusion about a homeless man's recent behavior; Dr. Manning's parents visit; victims of a hit-and-run accident.
After returning from maternity leave, Dr. Manning helps treat a teenager with an extensive history of medical issues; Dr. Choi goes above and beyond when a former Navy shipmate has a potentially life-threatening ailment; a budding romance.
Dr. Halstead's career is in jeopardy when he revives a terminally ill patient, despite a do not resuscitate order; a patient inspires Dr. Choi to seek advice from Dr. Charles; everyone is shocked by a revelation about a member of the staff.
A 9/11 hero with pulmonary fibrosis needs a new set of lungs; Sarah considers hospitals for her residency match while April and Maggie want to remain at Chicago Med; a teenage hockey player with an overbearing father is injured.
A patient with a life-threatening heart condition makes a decision that puts Rhodes and Choi at odds; the lawsuit against Halstead moves forward; a patient who was misdiagnosed has a flesh-eating bacterial disease; a girl with a contagious bacteria.
Nurse Lockwood is arrested for refusing to do a DUI blood test on a patient without his consent; Dr. Halstead discusses his impending lawsuit with his lawyer; Dr. Manning and Sharon Goodwin raise concerns about the nature of a baby's injuries.
A husband has an unusual request after the death of his wife; Dr. Charles tries to deal with a patient who wants to cut off his own arm; Dr. Rhodes is concerned about possible complications for a boy who swallowed magnets.
Dr. Choi is tested when an erratic patient takes drastic measures; Dr. Manning questions the circumstances behind a young boy's broken wrist.
A patient refuses medication for her pain; Dr. Halstead treats a former high school classmate; a pregnant woman has a big reason not to deliver her child.
Doctors Rhodes and Downey are at odds over a patient's emergency heart surgery; Dr. Choi and a paramedic respond to a call from an injured hoarder; a woman is bitten by her own dog.
April and Dr. Halstead can't agree on how to treat a homeless alcoholic with a broken leg; Dr. Manning realizes her wedding ring has gone missing; two elderly women with the same symptoms are linked in a surprising way.