Bekker takes drastic action to keep Rhodes from leaving Med for good; Halstead questions Manning's feelings about their upcoming wedding; Ethan receives shocking news about his sister, Emily; Charles mourns a loss.
Chicago Med, Fire and P.D. cross paths when a high-rise fire floods Med with victims, including Will and Jay Halstead's father; Rhodes must save the life and career of Stella Kidd; Manning treats a burn victim; Charles assesses a distraught Otis.
Halstead arranges a great deal on a wedding venue; Manning and Elsa treat an ill pregnant woman convinced that God will save her; the staff is conflicted about the law-breaking father of a 5-year-old patient; Rhodes opens his hybrid OR early.
Halstead is backed into a corner after unknowingly making a deal with a gangster; Manning fights for her dying patient, who is not a U.S. citizen; Rhodes and Bekker clash in the OR; Choi is shocked when he meets Emily's new boyfriend.
Halstead's first task as a criminal informant puts a strain on his relationship with Manning; Choi is shocked when the father of Emily's child ends up in the ED; Rhodes presses Bekker to reveal who anonymously donated funds for his satellite OR.
Manning and Halstead must act fast to save the life of a physically abused wife; Choi and April are shocked to learn the truth about their 14-year-old cirrhosis patient; Rhodes and Lanik go head-to-head in the ER.
After a deadly chemical spill, the ED goes on lockdown, threatening the lives of several patients and leaving one of Med's own hanging in the balance; Rhodes and Manning must perform lifesaving surgeries.
Choi and Charles use trickery to help a patient with an itch she can't help but scratch; Halstead and Manning argue over a tattooed coma patient; Rhodes angers Goodwin by going against orders to save a patient in the hybrid OR.
Halstead and Manning's wedding day is interrupted when Halstead is forced to make a house call; Charles treats a woman who stabbed her husband; Choi and April deliver a breech baby; Rhodes and Bekker operate on an FBI witness.
A shooting outside the hospital injures April and leaves the ED shaken up; Halstead returns after a stint in the witness relocation program; Charles and Elsa have an emotional confrontation; Bekker is reluctant to attend an event honoring Rhodes.
Halstead takes heat for making an unauthorized move to treat his pregnant patient; Choi becomes personally invested when treating a homeless veteran; Rhodes and Bekker deal with a patient who desperately needs a liver transplant.
Manning and her 3-year-old patient are trapped in a helicopter as the toddler's stats decline; Charles isn't sure Choi's alcoholic patient with liver failure has quite hit rock bottom.
Halstead hides the theft of his gun from a suspicious Manning; tensions are still high between Connor and Bekker, who take a risk operating on an HIV-positive patient; Hank breaks down when he sees a patient from his past.
Connor, who is in hot water with the hospital's Oversight Committee, handles a gunshot victim who has unexpected ties to Halstead; Maggie feels guilty about the return of a former patient; Charles has an awkward first date.
After witnessing a pickup truck plow through a street fair, Natalie and Maggie must make tough decisions on the fly; at the hospital, doctors and nurses are on high alert with the influx of patients; Dr. Charles' ex-wife comes to town with news.
Halstead treats a woman on the verge of freezing to death; Dr. Charles' ex-wife receives some concerning news; Choi handles a lymphoma patient with viral meningitis and a complicated family; Manning makes a house call.
When a car unexpectedly smashes through the ambulance bay doors, Dr. Choi makes some difficult decisions in an effort to save a worker trapped beneath the wreckage and April, who's also in danger.
An alarming phone call prompts Rhodes to rush out of an important surgery; Halstead comes to the aid of an FBI agent who is brought into the ED; Manning and Choi find themselves on opposite sides of a disagreement over doctor-patient confidentiality.
The hospital goes into lockdown mode when a man with a gun holds medical staff hostage; Goodwin is forced to make a tough decision; Dr. Rhodes begins to realize his time with his father is getting short.
Dr. Charles and Dr. Manning disagree on how to handle a patient who they discover is poisoning herself; Dr. Rhodes throws some serious accusations at Dr. Bekker; Dr. Halstead has suspicions about Natalie's new boyfriend; Dr. Choi tends to Bernie.
Caroline shares news that forces Dr. Charles to make a serious decision about their relationship; Maggie meets her sister's new boyfriend but danger may lie ahead; Dr. Rhodes experiences a huge loss; Dr. Choi and April face an unexpected challenge.