Dr. Max Goodwin shakes up the status quo on his first day as medical director of New Amsterdam, the oldest public hospital in the United States, while simultaneously dealing with his own personal and health issues.
Max avoids coming to terms with his diagnosis, instead focusing on the hospital and his wife's condition; Frome and Kapoor take a school district to New Amsterdam's in-hospital court over a young boy's extensive psychiatric medication.
Bloom treats an inmate from Rikers who is in a difficult position; Max gives a wealthy donor something to think about when he shows her the hospital; Reynolds begins to build his department; Sharpe battles skepticism from potential patients.
Max creates chaos when he volunteers New Amsterdam to take over for a short-staffed neighboring hospital; Frome has a crisis of conscience about the funding for a hospital garden; an eager resident learns a secret about Bloom.
A visiting journalist picks at the hospital's flaws while shadowing Max; Bloom and Reynolds have a major disagreement after Bloom makes a call against protocol; Kapoor confronts issues from his past.
Max faces the pressure of his first fundraising gala at the hospital; Frome struggles to break difficult news to his daughter; Bloom and Reynolds deal with the fallout of their argument; Kapoor and Sharpe work to help a sick father and son.
Max struggles to prioritize his own health when a complicated domino transplant procedure threatens to go sideways; Bloom re-evaluates her personal life; Frome makes progress on a long-standing case.
Max becomes overly invested in a patient's cancer treatment as his own comes to a crossroads; Reynolds celebrates his birthday with some help from the hospital; Kapoor grapples with a case that hits close to home.
The recipient of Max's sister's heart arrives at New Amsterdam just as Max convinces Sharpe to take a risk on his course of treatment; Frome works to help a trans patient; Bloom grapples with a difficult conversation.
As Max's life hangs in the balance, the doctors and staff rally to help him and support Georgia, but when Dean Fulton takes charge of the hospital, the team must fight to hold on to the legacy Max has created.
Reynolds confronts a difficult episode from his past; Max distracts himself from chemotherapy by taking on the case of a frequent-flyer patient; Frome helps a young man suffering from severe delusions; Sharpe worries about Bloom's attempt to detox.
Max and Frome question a respected doctor's fitness to work; Kapoor and Reynolds struggle to treat a blind woman's numerous health issues; Bloom and Sharpe continue to clash even as they work together to diagnose a patient's mysterious symptoms.
Max continues to work to solve underlying problems within the hospital despite his struggles with treatment; Reynolds makes the choice to do a costly surgery to determine an elusive diagnosis; Bloom must face her personal demons head-on.
Sharpe struggles when a case hits too close to home; Frome uncovers a patient's surprising past; Reynolds makes progress in his personal life after some difficult news.
Max bonds with the patients undergoing chemo with him, but a conversation leads him to struggle with his reality; Reynolds has difficulty handling a personal matter regarding a patient's family; Iggy struggles with a realization about his daughter.
When a history-making blizzard hits New York, Max and his staff must work together to keep the patients safe with few resources, even if it means taking to the streets of the city and braving the storm.
As the doctors continue to weather the storm without power, Max relies on an unlikely source to get the lights back on; Reynolds must get creative as he continues to work to save Hugh with very few resources.
Reynolds struggles to help a young cystic fibrosis patient who has curious symptoms; Kapoor finally comes face-to-face with Ella after their awkward encounter; Sharpe takes a major step in her personal life.
When an NYPD officer is hit by a car in the line of duty, the hospital is turned upside down to save her; Kapoor and Iggy work with a patient struggling with a previous surgery.
Max is forced to reckon with his diagnosis in a new way as things become more difficult for him; Reynolds is forced to address what could have gone wrong in a recent surgery.
Max goes head-to-head with hospital administration when he comes up with a new plan for patients without insurance; Iggy struggles with an accusation brought against him; Sharpe navigates her role as deputy medical director.