Stewie and Brian form a successful children's band, but when a girl comes between them, the band quickly falls apart; Chris takes a job managing Quagmire's sex life.
Brian and Lois try to help Chris manage his anger by encouraging him to take up a sport; Frank Sinatra Jr., Stewie and Brian open an Italian restaurant.
With the airline pilots on strike, Quagmire decides to become a gigolo to earn money; Brian gets a job at a hardware store for the health insurance.
Viewers are taken for a behind-the-scenes look at a "Family Guy" production week; Peter is replaced and pitches a new series to Fox Television Group Chairmen and CEO's Dana Walden and Gary Newman.
Taylor Swift agrees to go to the homecoming dance with Chris; Peter decides to become an Uber driver.
Fearing autism, Peter and Lois decide not to vaccinate Stewie, and they encourage the rest of Quahog to follow suit.
The cast re-enacts "The Great Gatsby," "The Adventures of Huckleberry Finn" and "Of Mice and Men."
When Peter overhears Carter's plan to save money by using toxic chemicals in the brewery's beer cans, he tells a journalist about it; Brian asks for Stewie's help when his driver's license expired.
Peter gets power hungry when he's asked to fill in for a mall Santa; Stewie and Brian decide to crash holiday office parties for free food, fun and women.
When Quagmire gets free plane tickets for a guys' trip to San Francisco, unforeseen events put his flying abilities to the test.
Professional football player Rob Gronkowski moves into the neighborhood; Stewie uses steroids to increase his new bees' honey output, but it makes them aggressive instead.
While the guys try to start a podcast, Peter goes solo and branches out as a DJ.; when Lois' allergy forces Brian to move into Stewie's bedroom, the two have a difficult time as roommates.
The guys decide to form a string quartet, but Peter doesn't make the cut; Brian is forced to be Carter's seeing eye dog.
Peter and the gang must intervene when a popular dating app sends Quagmire on the road to hedonism; Stewie finds out he has scoliosis.
Peter helps Joe with several crime cases but gets angry when Joe tries to take all of the credit; Brian convinces Stewie to join a football team and panics when he gets a concussion.
Peter opens up his own food truck business in an attempt to avoid the healthy food Lois forces him to eat; Meg joins a roller derby team, despite Chris thinking it's too dangerous.
Lois upstages Peter at a Red Sox fantasy baseball camp; Stewie runs away from home while Meg is watching him.
When Peter becomes the temporary principal at the high school, Meg uses his authority to get even with her bullies.
When Chris' Mexican girlfriend, Isabella, gets deported, he steps up to take care of her twin babies, only to find she can't return to the U.S.