James Woods invites Quahog residents to his mansion, and the evening turns into a murder mystery when guests end up dead.
Brian decides to confront Rush Limbaugh when he comes to Quahog for a book signing.
Lois' mom demands a divorce after discovering Carter is having an affair; Peter becomes Carter's wing man.
Peter and Joe perform painful and humiliating Halloween pranks on unsuspecting family and friends; Brian shows Stewie the ropes of trick or treating; Meg attends her first high school Halloween party.
Peter volunteers Lois to compete when he receives tickets to a boxing match.
One of Brian's books becomes a best-seller after Stewie becomes his manager; Lois decides that she and Peter need separate beds, leaving him to look for a new cuddle buddy.
After getting the brush-off from Santa at the mall, Brian and Stewie travel to the North Pole to teach Santa a lesson.
After years of drinking, Peter needs a kidney transplant; Chris and Meg write a poem to honor an important visitor.
Lois is forced to defend her reputation after the new local news anchor (Christine Lakin) does a story on her.
Brian and Peter are required to attend a 12-step program to deal with their drinking problems; Death (Adam Carolla) gives Peter a glimpse of what life would be like without alcohol.
Chris' search for a new hobby leads him to befriend a puppeteer named Franz, until the man's checkered past is revealed.
Meg offers to check on Joe while Bonnie is out of town; Stewie tries to become more evil.
When Chris and Meg trade roles with their parents, Chris works at the brewery and Meg runs the house.
The dry cleaner loses Peter's favorite shirt; Brian and Quagmire compete for the affections of each other's former flames.
When Mayor West and Lois' sister, Carol (Julie Hagerty), get married and move in with the Griffins, Stewie must give up his bedroom; Peter and Mayor West become friends.
Brian and Stewie go back in time to try and stop Bertram (Wallace Shawn) from killing Leonardo da Vinci.
Bonnie and Lois take a trip to Paris; Peter uses unorthodox teaching methods while homeschooling Chris and Meg.