Meredith and the team focus on helping Owen's sister after her shocking return; Amelia faces a conflict over a patient; Bailey gives Grey Sloan a makeover; the doctors meet a few new people.
Meredith struggles to come up with a new plan for Owen's sister; Jo makes a surprising choice regarding Alex; Andrew's sister's controversial research leads to a shocking discovery.
Harper Avery arrives and puts Bailey on edge; a familiar face from Meredith's past returns as a patient; Amelia tries to manage a secret.
Amelia confronts a difficult situation; Meredith deals with the fallout from her conversation with Nathan; Maggie finds herself at an awkward family dinner; Jackson receives big news; Richard and Bailey search for the stars of tomorrow.
Events leading up to Megan's kidnapping are revealed in a flashback; Owen and Megan work through old wounds.
Jackson invites the guys to relax with him on a day at sea; Arizona, April, and Maggie treat a woman who is hiding a deadly secret.
An accident at the county fair sparks memories for the doctors.
The doctors must get creative to treat patients after a hacker shuts down the hospital's computer system.
Jo faces her estranged, abusive husband; the hospital works with the FBI after a hacker compromises the computer system.
A young boy's case has a profound impact on the doctors of Grey Sloan Memorial; April faces a surprising patient; Jo deals with her estranged husband.
The stress of managing the hospital and coming to terms with Ben's decision to become a Seattle firefighter pushes Bailey to her limits.
April is in charge of the new surgical innovation contest; the doctors are eager to start their projects; Catherine's old friend has a shocking idea for Catherine and Jackson; Meredith treats a returning patient who inspires her project.
Seattle firefighters Ben Warren and Andy Herrera head to Grey Sloan after rescuing two boys who were injured in a house fire; the doctors work on their projects for the surgical innovation contest; Amelia brings Tom Koracick in to consult.
Maggie's relationship with Clive starts to progress; she invites him over for a game night to meet Meredith and Amelia; Meredith and Jo meet with the owner of the patent to the polymer they need for their project, who is a friend of the family.
Meredith tries to learn more about Marie Cerone's history with her mother; Jo applies for fellowships around the country, throwing Alex for a loop; Tom Koracick helps April acknowledge her crisis of faith.
Jackson must focus on the groundbreaking surgery he has scheduled with Catherine and Richard; Jo assists Bailey with a patient who used to be an astronaut.
April's crisis of faith is challenged by a patient; Meredith treats a patient who is a transplant surgeon from another hospital.
Amelia, Koracick and DeLuca perform a risky procedure to remove a young patient's brain tumor; Meredith and Jo work with different polymers to try to salvage their project submission; Richard's AA sponsor is admitted to Grey Sloan with a DNR.
An agent from U.S. Immigration and Customs Enforcement searches the hospital for an employee; Alex's patient wants to leave the hospital to enjoy her final days, but Alex feels differently; Arizona treats Matthew Taylor's baby.
Arizona shares some cookies that, unbeknownst to her, contain a special ingredient; Catherine reveals some shocking details to Jackson; Jo comes into the surgical room at mid-operation of a major surgery.
The hospital brings in crisis management to help sort out allegations against Harper Avery; nurse Olivia shows up at Grey Sloan with her son, throwing Alex and Jo for a loop; Sofia is having a hard time at school.
Alex and Jo go on a road trip to Iowa to find Alex's mom; Meredith gives a presentation on her mini-livers project, which attracts a lot of attention.
The doctors rally around one of their own who is seriously injured; Nicole Herman pays a visit and talks to Arizona about an exciting opportunity.