When their father goes missing, Dean and Sam follow the clues from his phone message until they get to a small town where they encounter a violent spirit called the Woman in White.
When they follow their father's coordinates to the middle of the woods, Sam and Dean come face-to-face with a mythical Wendigo.
Sam and Dean take on the angry spirit of a little boy causing a series of mysterious drownings that officials had written off as suicides.
On TransNational flight 2485, a man possessed by the spirit of a phantom traveler causes the plane to crash, leaving only five survivors.
Before she can kill again, Sam and Dean must destroy the violent spirit of Bloody Mary, unwittingly summoned by mischievous teens.
A shape-shifter adopts the likenesses of others and murders people.
When a mythical, vengeful creature terrorizes a small college town in Iowa, Sam and Dean race to find and destroy the Hook Man's bones before he comes for them.
Deadly swarms of bees, locusts, spiders and beetles overcome a town when a new housing development is built atop sacred Indian land.
A vision of a woman trapped in his childhood house haunts Sam, and he convinces reluctant Dean that they need to go home.
While searching for lost college students within an abandoned sanitarium, tortured spirits from the building's past begin to haunt Dean and Sam, turning brother against brother.
Sam and Dean contact their father, who tells them to stop searching for him and sends them to a small town in Indiana where people are being sacrificed to a pagan god.
While battling a demon, Dean is electrocuted, resulting in permanent damage to his heart and leaving him with only a couple of months to live.
Dean's first love asks him to come to Mississippi to investigate a string of racially motivated murders.
Sam has a premonition in which a man is killed, but the murder is made to look like a suicide.
Dean and Sam learn that the kidnappers they seek are not supernatural, but humans using their captives as human prey for a twisted hunting expedition.
When the brothers pursue Meg (Nicki Aycox), a woman responsible for a mysterious murder, she unleashes shadow spirits on them and sets a trap for their father.
Sam and Dean investigate a house haunted by a murderer.
Sam and Dean discover a witch is creeping into the bedrooms of children and stealing their "life force."
Sam and Dean race to figure out why all owners of an old family portrait end up murdered.
John Winchester reunites with his sons to avenge a friend's death.
Sam has visions of a family being attacked in a similar manner to his mother; Meg threatens to start killing people.