After Dean gives up hunting, Sam is mysteriously freed from his cage in hell and finds Dean to tell him he must rejoin the fight.
Sam investigates when the parents of missing babies are murdered; Dean reluctantly leaves Ben and Lisa to help Sam.
Sam and Dean seek Castiel's help when they investigate a case of police officers who seem to have been killed by Egyptian plagues.
Bobby asks Dean and Sam for help after Crowley refuses to return Bobby's soul; a deep secret about Crowley is revealed.
After young girls go missing, Dean and Sam realize vampires have come to town; Dean is bitten during a fight with two vampires.
Sam and Dean investigate a rash of suicides and discover that someone is invoking the Goddess of Truth to drive the victims crazy.
Dean is suspicious of Samuel's (Mitch Pileggi) motives; a hunting trip goes horribly awry.
Dean and Sam investigate what appears to be a werewolf killing.
Dean is abducted from a crop circle while investigating a UFO sighting; when he awakens, Dean discovers that he is dealing with fairies; Sam's investigation leads him to a world filled with elves, gnomes and a leprechaun.
Meg kidnaps Dean and Sam and tries to make them reveal Crowley's location; Sam tries to find out how to get his soul back.
Dean contacts Death in hopes of getting Sam's soul back; Sam asks Balthazar for a protective spell.
Bobby and Dean wait to see if Death was able to restore Sam's soul without complications; Dean must prove himself worthy of receiving the only weapon in the world that can slay a dragon.
Sam has flashbacks of a case he worked with Samuel; Sam and Dean follow the coordinates received in a text message to a small town, where Sam used to live; townspeople's comments surprise Dean.
Dean rushes home after hearing that Lisa is in trouble; Sam investigates murders that were part of a cruel joke.
After Raphael attacks Castiel and his allies, Balthazar tries to protect Sam and Dean by sending them to an alternate universe.
While searching for a monster, Dean, Sam and Bobby run into Gwen and Samuel (Mitch Pileggi); Samuel and Bobby have a heated argument.
Fate (Katie Walder) intervenes after Balthazar changes history by stopping the Titanic from sinking; Castiel tells Sam and Dean they must kill Fate if they want to survive.
While looking for a way to defeat Eve, Sam and Dean ask Castiel to send them back in time.
Dean, Sam, Castiel and Bobby find Eve in a small town where the citizens have been converted to demons; Eve decides to torture Sam and Dean by bringing their mother back as a demon.
Castiel talks about the war in heaven and what happened to set Raphael against him; Bobby suspects Castiel isn't being completely honest.
When a demon kidnaps Lisa and Ben, Sam and Dean are forced to work with an unlikely ally to save them.